La Crosse's location in the United States' upper midwest gives the area a temperate, continental climate.
The warmest month of the year is July, when the average high temperature is 84.1 °F (29 °C), with overnight low temperatures averaging 63.2 °F (18 °C).
It was a center of the lumber industry, for logs cut in the interior of the state could be rafted down the Black River toward sawmills built in the city.
La Crosse also became a center for the brewing industry and other manufacturers that saw advantages in the city's location adjacent to major transportation arteries, such as the Mississippi River and the railroad between Milwaukee and St. Around the turn of the 20th century, the city also became a center for education, with three colleges and universities established in the city between 18.
Myrick was disappointed to find that because many fur traders were already well-entrenched there, there were no openings for him in the trade.
As a result, he decided to establish a trading post upriver at the then still unsettled site of Prairie La Crosse. The spot Myrick chose to build his trading post proved ideal for settlement.
Males had a median income of $37,305 versus $32,145 for females. About 10.1% of families and 23.3% of the population were below the poverty line, including 19.7% of those under age 18 and 7.8% of those age 65 or over.
there were 51,320 people, 21,428 households and 9,691 families residing in the city.
The population density was 2,501.5 per square mile (965.6/km²).
There were 22,628 housing units at an average density of 1,102.7 per square mile (425.8/km²).
January is the coldest month, with high temperatures averaging 25.9 °F (-4 °C), with the overnight low temperatures around 8.9 °F (-14 °C).
According to 2009–2013 ACS estimates, the median household income was ,457 and the median family income was ,744.
The Black River empties into the Mississippi north of the city, and the La Crosse River flows into the Mississippi just north of the downtown area.