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Upgrade summary White paper Panorama™ is a simple, safe and highly accurate non-invasive prenatal screen for specific chromosome abnormalities including trisomy 21 (Down syndrome), trisomy 18 (Edwards syndrome), trisomy 13 (Patau syndrome), monosomy X (Turner syndrome), and triploidy.

Panorama™ analyzes fetal DNA that is circulating in the maternal blood and can be offered as early as 9 weeks of pregnancy. Panorama™ is also able to screen for other conditions that involve small pieces of missing genetic information, known as microdeletion syndromes.

In this event, Life Labs will contact the patient directly to arrange a new blood collection, at no charge.

The report will be sent directly to the ordering physician, who will discuss the result with the patient.

Life Labs will not provide results directly to patients.

Panorama’s high sensitivity ( Panorama™ Physician Pamphlet in English Healthcare Provider Guide to Results Video: Panorama™ NIPT video for Healthcare Professionals Webinars: Panorama™ Non-Invasive Prenatal Test (NIPT): Using Bioinformatics to Detect Multiple Common Chromosome Abnormalities The Explosive Growth of NIPT: Why You Should Care About Fetal Fraction Panorama™ Non-Invasive Prenatal Test (NIPT): Using Bioinformatics to Detect Multiple Common Chromosome Abnormalities White papers NIPT and Panorama’s™ approach Panorama™ Non-Invasive Prenatal Screening for Microdeletion Syndromes As an expectant mother, you deserve the reassurance that comes from having the most accurate and comprehensive genetic information available about your baby Panorama™ NIPT Patient Pamphlet in English, Hindi, Chinese and Arabic Panorama™ NIPT Microdeletion Patient Pamphlet in English VIDEO for Patients: Panorama™ NIPT video Most people have 23 pairs of chromosomes for a total of 46 — two copies of each pair.

Panorama™ is highly effective in determining if there is an extra chromosome or if there is only one chromosome where there should be a pair.

Panorama Microdeletions Extended Panel Sample Report Panorama™ sequences only those chromosomes of interest (13, 18, 21, X, and Y) using single-nucleotide polymorphisms (SNPs).

Panorama’s SNP methodology is accurate at fetal fractions (ff) as low as 4% and can be used earlier in pregnancy.

Sample report In rare cases, Panorama™ is unable to provide results even after a redraw.

The patient will be fully reimbursed in this event.

A microdeletion syndrome is based on where the missing information is located (i.e.: on which chromosome) and its effects.

Panorama can screen for the most common microdeletion syndromes, listed below.

There are several possible results: High Risk result: Indicates that there is a very high chance that the fetus has a one of the chromosome conditions being tested for. In the event of an abnormal result, the ordering physician will be contacted by a certified genetic counsellor at Life Labs.

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